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ea0026oc3.1 | Bone/Reproduction | ECE2011

Mild hyponatremia as a risk factor for fractures: the Rotterdam study

Hoorn E J , Rivadeneira F , van Meurs J B J , Ziere G , Stricker B H Ch , Hofman Albert , Pols Huibert , Zietse R , Uitterlinden A G , Zillikens M C

Introduction: Recent studies suggest that mild hyponatremia is associated with fractures, but prospective studies are lacking.Aim: Our aim was to study whether hyponatremia is associated with fractures, falls and/or bone mineral density (BMD).Methods: Five thousand two hundred and eight elderly men and women with serum sodium assessed at baseline were included from the prospective, population-based Rotterdam Study. The following da...

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ea0034oc1.3 | Young Endocrinologists prize session | SFEBES2014

Angiogenic factors sFlt1 and PlGF are novel determinants of newborn thyroid (dys)function: the Generation R Study

Korevaar Tim , Schalekamp-Timmermans Sarah , Visser Theo , de Rijke Yolanda , Visser Edward , Visser Willy , de Muinck Keizer-Schrama Sabine , Hofman Albert , Hooijkaas Herbert , Tiemeier Henning , Bongers-Schokking Jacoba , Jaddoe Vincent , Steegers Eric , Medici Marco , Peeters Robin

Introduction: Adequate thyroid hormone availability during early life is crucial for normal child growth and development. Fetal growth in utero heavily depends on angiogenesis. Placental growth factor (PlGF) is a proangiogenic factor sharing high homology with vascular endothelial growth factor (VEGF) whereas soluble FMS-like tyrosine kinase-1 (sFlt1) is a potent antagonist of VEGF and PlGF signaling. Since the thyroid is a highly vascularized organ, we hypothesized t...

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Endocrine Abstracts

Mild hyponatremia as a risk factor for fractures: the Rotterdam study

Angiogenic factors sFlt1 and PlGF are novel determinants of newborn thyroid (dys)function: the Generation R Study

BiosciAbstracts